I Believe the Correct Term is "Elephantitis"
Generally speaking, in our society, having big nuts is considered a good thing, and having small nuts is considered embarrassing.
Unless, of course, your enormously swollen nuts put you in the hospital, as they have recently done to Browns TE Kellen Winslow.
Dr. Edwards*: Dr. Richards, I came as soon as I saw the call. What are we looking at here?
Dr. Richards (highlighting Winslow's nuts with a laser pointer): It appears as though the patient is suffering from an acute case of blue balls.
Dr. Edwards: My God. Of all the horrible things you see in this line of work, you never quite get used to this.
* No relation to Braylon Edwards.